1. 100 women with anovulatory infertility were divided into 2 groups: one comprised of women with polycystic ovary syndrome, and the other without. Before treatment, the women had laboratory results of high plasma LH levels. The women were treated with Chinese herbal medicine for eight weeks. Following treatment, LH levels were significantly reduced, and menstrual cycle improvement, including successful ovulation, was seen in the polycystic ovary syndrome group and in the non-polycystic ovary syndrome group.

Ushiroyama T , Ikeda A , Sakai M , Hosotani T , Suzuki Y , Tsubokura S , Ueki M. Effects of unkei-to, an herbal medicine, on endocrine function and ovulation in women with high basal levels of luteinizing hormone secretion. Journal of Reproductive Med. 2001 May; 46(5):451-6.

1. One hundred and seven PCOS patients were randomly divided into two groups, the treated group was treated with Chinese herbal medicine, while the control group was treated with clomiphen. Significant difference was shown in the aspect of BMI, F-G score, serum testosterone (T), luteinizing hormone (LH) and OGTT, etc. between the two groups. The pregnancy rate of the treated group (65.7%) was markedly higher than that of control group (25.0%).

Hua L , Wu YN , Zhang JM. Clinical study of yishen jianpi yangxue tongli therapy in treating polycystic ovary syndrome. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003; 23(11):819-22.

1. A study involving 103 women with luteal phase defects treated with Chinese herbal medicine and 94 control patients was conducted. Plasma LH levels were significantly decreased, beta-estradiol in the follicular phase significantly increased, and progesterone (66.7%) in the mid-luteal phase significantly increased. Significant development of the dominant follicle and endometrium was also observed in patients treated. Significant prolongation of the luteal phase was measured by basal body temperature. There was a 79.6% rate of correction of luteal phase defects in patients treated. The pregnancy rate in patients desiring pregnancy was 49.5%.

Ushiroyama T , Ikeda A , Higashio S , Hosotani T , Yamashita H , Yamashita Y , Suzuki Y, Ueki M. Unkei-to for correcting luteal phase defects. J Reprod Med. 2003; 48(9):729-34.

1. The effects of Chinese herbal medicine on endometriosis and the uterine arterial blood flow was studied in 53 women with endometriosis who manifested with dysmenorrhea, menoxenia, ovarian chocolate cysts and enlarged uterus. The control group consisted of ten women with normal regular menstrual cycle. This research dealt with the method of using the hemodynamic index of uterus arterial blood flow. After treatment the blood flow amount of uterus arteries of 53 cases (study group) obviously decreased and their uterus arterial blood flow speed reduced markedly as compared with pre-treatment status. After treatment for 3.5 months, symptoms such as dysmenorrhea (period pain) and menstrual disorder basically disappeared. 22 ovarian chocolate cysts became smaller and 16 disappeared. The pregnancy rate was 45%.

Zhu WX, Cheng XA. Clinical study of the treatment of endometriosis with promoting blood circulation and stasis removing method. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1993 Jan; 13(1):16-8;4.

1. One hundred and twenty patients with fallopian tube obstruction were randomly divided into three groups, the TCM-WM group, treated with integrative traditional Chinese and western medicine, the TCM group treated with Chinese herbal medicine alone and the WM group treated with western medicine alone. After treatment, the fallopian tube patency rate was 86.7% and the pregnant rate 85.0% in the TCM-WM group, while in the TCM group was 66.7% and 63.3% respectively, and in the WM group 53.3% and 50.0% respectively. Comparison among the three groups showed that the effect in the TCM-WM group (fallopian tube patency rate was 86.7% and the pregnant rate 85.0%) was significantly superior to that in the other two groups.

Kang JL , Xia W , He QY. Clinical study on treatment of oviduct obstruction by integrative traditional Chinese and Western medicine. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001; 21(6):416-8.

1. Twelve patients with recurrent miscarriage due to an immunological component who had shown positive anti-phospholipid antibodies were treated through the administration of a Japanese modified traditional Chinese herbal medicine. The patients had experienced a total of 27 spontaneous abortions in their previous pregnancies. The positive value of antiphospholipid antibodies returned to negative in 9 patients out of 12 patients through the treatment. Out of 12 patients, 10 patients continued their new pregnancy uneventfully. (Success rate: 83.3%).

Takakuwa K, Yasuda M, Hataya I, Sekizuka N, Tamura M, Arakawa M, Higashino M, Hasegawa I, Tanaka K. Treatment for patients with recurrent abortion with positive antiphospholipid antibodies using a traditional Chinese herbal medicine. J Med. 1996; 24(5):489-95.

1. In 40 women with threatened miscarriage and a history of miscarriage, their blood tests showed threatened abortion (TA), compared to the blood test of normal pregnant women (The plasma beta-EP level in TA was significantly higher than that in normal pregnant women. On the contrary, plasma GnRH, HCG and P4 were obviously lower in TA as compared with those of the normal cases. After treatment with Chinese herbal medicine that supported reproduction and blood circulation and protected the fetus, 36 of the 40 patients continued their pregnancy without symptoms of TA, and the above-mentioned four criteria measured at 10-12th week of gestation were similar to those of normal pregnancies.

Sun F, Yu J. Effect of TCM on plasma beta-endorphin and placental endocrine in threatened abortion. Zhongguo Zhong Xi Yi Jie He Za Zhi . 1999 Feb; 19(2):87-9.